Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis
نویسندگان
چکیده
منابع مشابه
Tissue factor-dependent chemokine production aggravates experimental colitis.
Tissue factor (TF) is traditionally known as the initiator of blood coagulation, but TF also plays an important role in inflammatory processes. Considering the pivotal role of coagulation in inflammatory bowel disease, we assessed whether genetic ablation of TF limits experimental colitis. To this end, wild-type and TF-deficient (TFlow) mice were treated with 1.5% dextran sulfate sodium (DSS) f...
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There is growing evidence for an interplay between inflammatory and coagulation pathways in acute and chronic inflammatory diseases. However, it remains unclear whether components of the coagulation pathway, such as tissue factor (TF), contribute to intestinal inflammation, and whether targeting TF will blunt the inflammatory cell recruitment, tissue injury, and enhanced thrombus formation that...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2011
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2011.00138